The solution containing Tc-99m is then used to prepare radiopharmaceuticals. This new radiopharmaceutical is a pragmatic alternative to OIH and offers advantages not only for scintigraphic imaging but is also suited for quantitative renal function studies. The saline solution removes Tc-99m and leaves behind Mo-99. The plasma extraction efficiencies of both agents, measured during surgery (n = 5), did not indicate an extrarenal elimination of 99mTc-MAG3.
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Competitive inhibition of the tubular transport system by p-aminohippurate (PAH) (20 patients) revealed a distinctly higher suppression of the 99mTc-MAG3 clearance than of OIH which indicates a lower affinity of the 99mTc complex to the tubular cell. Simultaneous steady-state measurements resulted in a 1.5-fold higher clearance of OIH than of 99mTc-MAG3 (n = 124). These showed that 99mTc-MAG3, compared with OIH, has a higher plasma-protein binding, an essentially higher intravascular concentration, a smaller volume of distribution and, with practically identical biologic half-lives, a correspondingly lower clearance.
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Technetium 99 m generator generator#
This generator provides a closed system for the production of sterile metastable technetium Tc-99m, which is produced by the decay of molybdenum Mo-99. For interpretation of clinical findings, extensive pharmacokinetic studies were performed on patients. The Ultra-Technekow DTE Generator is prepared with fission-produced molybdenum Mo-99 adsorbed onto alumina column shielded by lead, tungsten, or depleted uranium. A gamma-emitting radionuclide imaging agent used for the diagnosis of diseases in many tissues, particularly. The mechanism of action of technetium tc-99m sodium pertechnetate is as a Radiopharmaceutical Activity.
![technetium 99-m generator technetium 99-m generator](http://patentimages.storage.googleapis.com/WO1999040882A2/imgf000046_0001.png)
Technetium-99m is a short-lived form of Tc-99 that is used as a medical diagnostic tool. Technetium-99 can be found as a component of nuclear waste. GAS GENERATOR, KRYPTON, KR - 81M MPI STANNOUS DIPHOSPHONATE, TECHNETIUM TC. Technetium-99 is produced during nuclear reactor operation, and is a byproduct of nuclear weapons explosions. Technetium-99m-mercaptoacetylglycylglycylglycine (99mTc-MAG3) is introduced to replace o-iodohippurate (OIH) for renal function studies. Technetium tc-99m sodium pertechnetate is a Radioactive Diagnostic Agent. LACTULOSE MEDI PHYSICS CINTICHEM TECHNETIUM 99M HEDSPA, TECHNETIUM TC. Tc 99m generator In sizes from 830 mililcurles up to 16,600 milllcuries (in approximately 830 millicurie Increments) of Molybdenum Mo 99 as of 10:00 P.M.